Guest appearances on The Guitar Show have featured many artists of different genres. Bands and soloists alike include:

• Aerial Acoustics
• Aaron Leone
• Anthony Mazzella
• Arty Thanasoulis
• Barry Barrett
• Bennett Harris
• Ben Sher
• Bill Dudley
• Bill Scherer
• Bob Einfrank
• Bob Galassi
• Bob Reidel
• Brian Kerrins
• Case Brothers
• Chad Mcloughlin
• Chris Slagle
• Cintron Brothers & Chuscales
• David Gross
• Dennis McCorkle
• Enrique Vargas
• Fam'ly Jewels
• Fredrick Draper
• Fade To Black
• Frank Vento
• Gordon Russel
• Gordon Giltrap
• Grant Schinto
• Groundhog
• Hank Decora
• Harvey Reid
• Horse Country Bluegrass Band
• Howard Greenblatt
• Janko
• Jeff Tilman
• Jerry Bruno
• Jim Coyle
• Jim Goodin
• Jim Keyes
• Jimmy Pfoh
• Joe Brady
• Joe Scarfone
• John Abercrombie
• John Basile
• Jon G Smith
• Jon Schole
• Judimarie Canterino
• KJ Denhert
• Larry Kolker "Long Island Slim"
• Larry Cooley
• Lawerence Decasale
• Little Toby Walker
• Michelle Vecchione
• Marc Foxhall
• Marcello Vestry
• Mark Hitt
• Mike Greenberg
• Mike Coppola
• Nick Bukuvales
• Niko
• Paul "Delta Boy" Ruzenski
• Paul "Sequence" Ferguson
• Peter Calo
• Phil Dollard
• Philip Marino
• Preston Reed
• Ray Schinnery
• Rhett Tyler
• Rich Dashnaw
• Robert Knippel
• Roy Book Binder
• Sandy Lucci
• Sean Byrne
• Sisters of the Blessed Sacrament
• Steve Adelson
• Steve Booke
• Steve Yablonsky
• Sue Larsen
• Susan Bergson & Tom Formichella
• Terre Roach
• T.J. Evans
• Utopia Pkwy
• Woody Mann